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Pharmaceutical freeze dryer cleaning and drug formulation cooling problems

Release Date: 2019/7/11 17:04:53 .
Browse: 1038

Pharmaceutical freeze dryer cleaning and drug formulation cooling problems
The freeze dryer (freeze dryer) consists of a refrigeration system, a vacuum system, a heating system, and an electrical instrument control system. The main components are drying ovens, condensers, refrigeration units, vacuum pumps, heating/cooling devices, etc. Freeze-drying is referred to as lyophilization, which is a method in which an aqueous substance is first frozen into a solid state, and then the water therein is sublimated from a solid state into a gaseous state to remove water and preserve the substance. The lyophilizer originated in the 1920s vacuum freeze-drying technology after several decades of ups and downs, and made great progress in the last 20 years. In the 21st century, vacuum freeze-drying technology has become more and more popular with people due to the advantages unmatched by other drying methods. In addition to its wide application in the fields of medicine, biological products, food, blood products and active substances, its application scale and field Still expanding. To this end, vacuum freeze drying is bound to become an important application technology in the 21st century.
The pharmaceutical vacuum freeze dryer cleaning and the cooling of the pharmaceutical preparations, the freeze-drying of the medicine first freezes the aqueous material below the eutectic point temperature, so that the free water therein becomes ice, and then, under the appropriate vacuum condition in the freeze-drying chamber, The heating method is a technique in which the ice is sublimated or the adsorbed water is evaporated, escaped from the material, and removed, thereby obtaining a dried product.
During the sublimation process, there will be sublimation airflow continuously escaping out of the material. Under the action of the airflow, some small pieces of material will drift to the corners of the cabinet with the airflow. If it is not removed, it may not only cause different materials. Cross-infection, when more serious, will accumulate microorganisms after prolonged accumulation, causing bacterial growth, which is very harmful to pharmaceutical preparations and seriously affects the quality of medicines. However, the existing fixed sprinkler has a small spraying range, and can only spray the box body or the partition part vertically, and can not clean many dead corners of the box. Therefore, it is necessary to effectively clean all corners of the box. Avoid breeding bacteria in the corners. On the other hand, during the circulating flow of the heat transfer oil, when the temperature of the hot oil is too high, a certain pressure will be exerted on the circulating pump, causing it to be overheated and damaged for a long time, affecting the service life and efficiency.
The following provides a pharmaceutical freeze dryer that can effectively clean all corners of the cabinet, and another purpose is a pharmaceutical freeze dryer that can reduce the temperature of the heat transfer oil and avoid overheating and overpressure of the circulation pump.
The pharmaceutical freeze dryer comprises a tank, a refrigeration unit and a heat transfer oil transfer device, wherein the tank has a plurality of layers of partitions, and the plurality of bottles are placed on the partitions, and the refrigeration unit and the hydraulic transmission device respectively Connected to the partition, the freezing unit and the hydraulic conveying device respectively transport the heat-conducting oil to the partition to freeze the preparation on the partition, wherein the top of the box is provided with a rotary sprinkler, and the rotary spray is sprayed The head is sprayed with water to cool the formulation on the separator.
Preferably, the rotary sprinkler is mounted on the top plate of the box by a lifting rod, and is disposed between the first layer partition and the top plate of the box, and adjusts between the shower head and the partition plate by the lifting rod The spacing of the lifting rod is fixed to the top plate of the box body at one end, and the rotary sprinkler head is mounted at the other end, and the rotary sprinkler head is driven to rotate with the lifting rod as a shaft, so as to move up and down to adjust the height of the sprinkler head.
Preferably, the pharmaceutical freeze dryer further adds a cooling system comprising a valve and a heat exchanger, the valve being disposed between the refrigeration unit and the inlet end of the diaphragm. The cooling system further cools and lowers the heat transfer oil to reduce the pressure on the circulating pump caused by the heat transfer oil overheating.
Compared with the prior art, the pharmaceutical freeze dryer for cooling pharmaceutical preparations adopts a rotary sprinkler instead of a fixed sprinkler, and is spray-cleaned in the box in a multi-directional, multi-angle, and liftable manner. Spraying and cleaning all corners of the box, the cleaning effect is better, solving the problem that the dead corner on the box or the partition is not easy to clean; in addition, a cooling system is added to cool the heat transfer oil again to reduce the heat transfer oil overheating The influence of the pressure brought by the circulation pump effectively extends the life of the circulation pump.
Vacuum freeze-drying technology has a wide range of applications in the fields of bioengineering, pharmaceutical industry, food industry, materials science and deep processing of agricultural and sideline products. Freeze-drying of drugs includes two parts: western medicine and traditional Chinese medicine. Western medicine freeze-drying has been developed in China, and many larger pharmaceutical plants have freeze-drying equipment. In terms of traditional Chinese medicine, it is currently limited to lyophilization of a small amount of Chinese medicinal materials such as ginseng, velvet, yam, and Cordyceps sinensis. A large number of proprietary Chinese medicines have not been freeze-dried, which is far from the foreign countries. In the field of biotechnology products, freeze-drying technology is mainly used for the production of drugs such as serum, plasma, vaccines, enzymes, antibiotics, hormones; biochemical inspection drugs, immunology and bacteriology; drugs; blood, bacteria, arteries, bones Long-term preservation of skin, cornea, nerve tissue and various organs.

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