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Your Location: Home >> News >> Technical support >> Development Status and Trends of Floor Model Manifold Freeze Dryers

Development Status and Trends of Floor Model Manifold Freeze Dryers

Release Date: 2018/12/25 16:15:08 .
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Development Status and Trends of Floor Model Manifold Freeze Dryers
Floor Model Manifold Freeze Dryers are widely used in many fields such as medicine, pharmaceuticals, biological research, chemistry, and food. The lyophilized articles can be stored for a long time, and can be restored to the state before lyophilization after adding water, and can maintain the original biochemical characteristics. Songyuan Huaxing series laboratory type freeze-drying machine, the model is complete, can meet the requirements of various batches of the laboratory, various freeze-drying methods, and complete various freeze-drying tests well.
Floor Model Manifold Freeze Dryers are suitable for ampoules. For the preservation of microbial strains such as bacteria and fungi, the laboratory uses the ampoule storage method. The sample was freeze-dried and packaged in a small ampoule. It has the advantages of long storage period, small variation, easy storage and wide application range. Standard 24 rubber sealing valves for ampoules and 24 amps. Special requirements can be customized.
Floor Model Manifold Freeze Dryers should first check the drain valve rubber seal valve. It is recommended to remove the right side plate of the machine and then unscrew the drain valve, block the nozzle with a rubber stopper and then vacuum.
Floor Model Manifold Freeze Dryers If the vacuum is required for the job, the problem is with the drain valve seal. Usually caused by adhering dry residue and rag head. It is recommended that the vacuum is used to blow off the deposit on the drain valve (80).
If the above does not solve the problem, the valve must be cleaned or replaced. Check that the vacuum pump is filled with oil. The lyophilizer must be replaced with dirty oil. The lyophilizer checks the pressure. Check that the dry empty grinding port is evenly coated with vacuum oil throughout the sealing surface. When using a drying chamber with 8 vacuum rubber sealing valves, the vacuum rubber sealing valve should be removed, the interface should be blocked with a rubber plug, vacuumed for inspection and vacuum rubber sealing valves should be replaced for inspection. Check the vacuum sensor and see if it has any water evaporation residue. Floor Model Manifold Freeze Dryers vacuum sensors have a limited life and should be replaced if damaged.
Floor Model Manifold Freeze Dryers are classified according to their use. There are experimental freeze dryers and production freeze dryers. According to the size of the dry shelf area, there are three types: small, medium and large (the freeze-dry area is below 1m2). Small, 1~10m2 is medium, 10~50m2 is large); according to freezing method, there is freeze-dry combination and freeze-dry separation; divided by intermittent, semi-continuous and continuous according to operation mode; Shape division, there are square, round and tunnel type; according to the degree of automation, there are manual, semi-automatic and fully automatic [2]. Floor Model Manifold Freeze Dryers are mainly composed of control system, vacuum system, refrigeration system and circulation system. In addition to the above components, the medicinal Floor Model Manifold Freeze Dryers also has isolation system, hydraulic system and in-situ cleaning system CIP (Clean in place). And the in-situ sterilization system SIP (Sterilization in place), etc. [3]. The following is a brief introduction to the development status and trends of refrigeration systems, control systems and freeze-drying production lines.
Refrigeration system development
In recent years, the refrigeration compressors of domestic freeze-drying machines are basically purchased from abroad, generally adopting German and Italian brands, and the performance is good, but the minimum power of refrigeration compressors obtained through international procurement is 5 (from 5 to 35). It is suitable for the production of experimental freeze dryers below 1m2. Therefore, the domestic experimental Floor Model Manifold Freeze Dryers manufacturers generally use domestic refrigeration units, which have the problems of large energy consumption and poor matching. At present, some manufacturers adopt a cascaded cryogenic refrigeration system, which uses two imported single-stage compressors to form a cascade refrigeration method with higher stability and performance [4].
The Liquid Nitrogen System (LN2) is a lyophilizer that uses liquid nitrogen as a source of cooling to cool the system. The air contains 78% nitrogen, which is convenient to prepare. It is an inexhaustible environmentally friendly energy source. It is widely used in modern industrial fields. At present, the domestic manufacturer of liquid nitrogen refrigeration system is Shanghai Dongfu. Dragon. The advantages of LN2 refrigeration are:
(1) The refrigeration system has high reliability, good stability and low noise.
(2) The limit temperature is low and the cooling capacity is large, and it is especially suitable for freeze-drying products containing organic solvent.
(3) The cooling speed is fast and the cooling capacity is high.
(4) Power consumption, simple maintenance and good economy.
(5) The recovered nitrogen can be reused without polluting the air [5].
However, some shortcomings restrict the large-scale application of LN2, such as the filling of liquid nitrogen, and the current cost is also high. However, with the further development and continuous improvement of related technologies, the application of this highly efficient and environmentally friendly refrigeration method will become more and more extensive.
Floor Model Manifold Freeze Dryers control of the freeze-drying process is a key indicator of the GMP standard. The implementation of the fully automatic control system allows the Floor Model Manifold Freeze Dryers product to be lyophilized with good reproducibility and enhance the Floor Model Manifold Freeze Dryers. Stability and product quality. The current development of control systems is mainly in the following aspects:
(1) Provide multi-level operation authority;
(2) Provide complete automatic or manual control;
(3) Provide automatic control such as SIP, CIP, and defrosting;
(4) Provide complete automatic cycle editing and calling;
(5) Provide a variety of real-time and historical data queries, provide batch records and inquiries;
(6) Provide multi-user operation records and queries;
(7) Provide a variety of alarm and event records;
(8) Meet the requirements of FDA 21CFR Part11, with electronic signature, etc.
 

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