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Your Location: Home >> News >> Technical support >> Application of vacuum freeze dryer in biopharmaceutical field

Application of vacuum freeze dryer in biopharmaceutical field

Release Date: 2019/3/15 17:18:02 .
Browse: 1005

Application of vacuum freeze dryer in biopharmaceutical field

With the advancement of modern science and technology, the development of bio-pharmaceutical industry has been promoted. Traditional Chinese medicine production has been freed from the past “workshop” production methods, widely used modern scientific freeze-drying technology, applying new technology, new accessories, new medicine freeze dryer Equipment, research and development of new dosage forms of traditional Chinese medicine, preparation and production of new preparations, thus fundamentally changing the backward appearance of the pharmaceutical preparation field, and improving the level of bio-pharmaceutics as a whole. Therefore, vacuum freeze-drying technology has also been widely used in the field of traditional Chinese medicine.

1. Processing and preservation of Chinese herbal medicines. Freeze-drying technology can be used for the new processing and active preservation of Chinese herbal medicines.
The vacuum freeze-drying technology can very well ensure the appearance, color and odor of the medicinal material itself in the application process, and it also has very good dehydration in the application process, and can also decompose the active ingredients in the application process. And the loss is reduced to a small level of zui, ensuring the activity of the medicinal ingredient itself. Lyophilization is usually applied to the processing of ginseng, American ginseng, winter insects, and Sanqi.
Taking ginseng as an example, the ginseng obtained by drying ginseng by freeze-drying technology is not very obvious under the influence of lyophilization process conditions. Compared with fresh ginseng, the difference of sensitive components is very small, and the ginseng produced by drying method is very obvious in the loss of total saponins and heat sensitivity, and the proportion of monomer saponin is also in this process. A very obvious change has been produced, which fully proves that the freeze-drying method is a relatively reasonable drying method. In the process of production of Panax notoginseng, the three-seven-yellow produced by the freeze-drying method is more soft and odorous. It is more concentrated, and it is easier to cut and pulverize. The content of saponin is 2% higher than that of the traditional method, and it is more dominant in quality.
2. Modern Chinese medicine preparations.
1 Chinese medicine liposomes and nanoparticles. Liquid liposome is a kind of suspension emulsion, which is unstable in nature, prone to coagulation and fusion, and causes leakage of its encapsulated drugs. Liposomes can only be stored for a few weeks in a liquid state, limiting application. The lyophilization technology further expands the advantages of liposome and the like as a drug carrier, and can be separately prepared and stored, which can prolong the action time of the drug, reduce its toxic side effects, and improve bioavailability.
2 Chinese medicine freeze-dried powder needle. The traditional Chinese medicine compound for injection or the lyophilized powder needle prepared by one side is superior to the conventional injection solution in terms of moldability and water solubility, and the stability of the freeze-dried powder needle is also greatly improved.
3 Chinese medicine oral tablets. Freeze-drying can also be used for the preparation of oral tablets for traditional Chinese medicine.
3. Western medicine preparations.
1 Western medicine liposome. The freeze-drying technology of western medicine preparations is relatively mature. At present, the larger pharmaceutical factories in China have freeze-drying equipment. Many dosage forms (injections, oral preparations, eye drops, etc.) have adopted the freeze-drying process to improve the quality and shelf life of the medicines. Such as clarithromycin, mifepristone, retinoic acid and so on.
2 Western medicine freeze-dried powder needle. Western medicine is made into freeze-dried powder needle, which can be used for long-term storage; easy to achieve sterility operation; accurate and accurate; rehydration performance, such as propyl sulfoxide, amoxicillin sodium, etc.
3 other dosage forms. Oral fast disintegrating tablets have the advantages of convenient use, accurate dosage, rapid disintegration, and small stimulation to the digestive tract. In addition to the above advantages, the orally disintegrating tablet prepared by the lyophilization method can also prevent the decomposition and deterioration of the drug due to high temperature, and the microorganism is not easy to grow and reproduce due to low water content of the product, and is easy to store.
4. Biological drugs. For the chemical and physical properties of most biopharmaceuticals, lyophilization has been proved to be a very effective means. Freeze-drying is carried out at low temperature and in a high vacuum state, so it is especially suitable for many heat-sensitive substances; the dried material is loose and porous, and the dissolution is rapid and complete; the lyophilized product is thoroughly dehydrated, and can be vacuum or nitrogen-filled and protected from light. The shelf life is long.
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