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Your Location: Home >> News >> Technical support >> Is the pilot freeze dryer vacuum really good?

Is the pilot freeze dryer vacuum really good?

Release Date: 2018/7/6 11:49:09 .
Browse: 414

Is the pilot freeze dryer vacuum really good?

The pilot freeze dryer is mainly composed of control system, vacuum system, refrigeration system and circulation system: in addition to the above components, the medicinal pilot freeze dryer has hydraulic system, in-place cleaning system and in-situ sterilization system. The medicinal flash dryer is the key equipment in the production process of the aseptic freeze-dried preparation. Due to the particularity of the medicine, the relevant departments have clearly defined the material and performance of the pilot freeze dryer. Although the current pilot freeze dryer has met the production requirements, it still has the following shortcomings in terms of economic benefits, product quality, production operation, etc. The most important point is that the vacuum is too high, which is not conducive to product sublimation! During the freeze-drying process of the product, the degree of vacuum in the environment has a direct influence on the length of the freeze-drying cycle. If the degree of vacuum is too low, the sublimation rate will drop significantly; if the degree of vacuum is too high, the heat convection will be too poor, and the freeze-drying rate will be significantly reduced.
The pilot freeze dryer process is divided into two phases, one is the freezing phase, and the other is the vacuum phase (also called the drying or sublimation phase). Many people think that the lower the vacuum in the freezing temperature and the drying stage, the better, in the process of using the lyophilizer, but it is not.
The characteristics of each material are different, so the respective crystallization points are different. The freezing temperature and the water-trapping temperature of the freeze-drying machine are mainly determined according to the characteristics of the material itself, not the lower the better, the temperature is too low. Waste energy consumption, and secondly, the time in the pilot freeze dryer.
The drying stage can be further divided into pre-drying, primary drying and secondary drying. The application of each stage and the degree of dryness that can be achieved are mainly determined by the drying process.
The pre-drying of the pilot freeze dryer refers to the first stage of drying that mainly removes free moisture;
The pilot freeze dryer is a dry stage that mainly removes free moisture, and one drying can only be carried out in a vacuum;
The secondary drying of the pilot freeze dryer refers to the drying phase from the start of freeze drying to the complete removal of moisture contained in the solid state of polymerization.
With the accelerated pace of people's life and the increasing emphasis on people's health, Chinese medicine freeze-dried products will be widely recognized and accepted by the public. With its unique superiority, freeze-drying technology will become a new opportunity for the development of Chinese medicine pharmaceutical industry in the future. The research and promotion of freeze-dried powder technology has far-reaching significance especially in the case of unstable Chinese medicine or single-flavor medicine in some injections.
After years of clinical observation and patient feedback, many Chinese herbal medicine freeze-dried powder injections not only have good properties and water solubility, but also greatly improved their stability. For example, the universal application of traditional Chinese medicine Shuanghuanglian powder injection is proved. At the same time, the vacuum freeze-drying technology can also be applied to the preparation process of traditional Chinese medicine liposomes, nanoparticles, and nanoemulsions, for example, prolonging the action time of the drug in vivo, reducing toxicity, and improving bioavailability. Vacuum freeze-drying technology is also the most ideal method for processing yam products. Vacuum can avoid oxidation. Low temperature can make protein, amino acid, soap and mucus in yam not damaged, and reduce nutrient loss.
In 2016, the relevant national ministries and commissions issued the “2016-2020 China Traditional Chinese Medicine Pieces Market Investment Analysis and Prospect Forecast Report”, focusing on the present, the spring of the Chinese medicine decoction piece industry is coming, the national policy is strong support for large and medium-sized enterprises and for small enterprises. The integration and mergers indicate that the Chinese pharmaceutical industry will inevitably develop in the direction of scale, unification, stricter quality control and market concentration. Therefore, advanced technology will inevitably play its full role, and the freeze-drying technology of traditional Chinese medicine decoction pieces will also exert its new vitality.

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